• Lorrany da Silva Avanci, Thiago Guedes Pinto, SouzaDaniel Vitor deDV0000-0002-0999-5847Universidade Federal de São Paulo, Department of Biosciences - Santos (SP), Brazil., Lais Vales Mennitti, Daniel Araki Ribeiro, and Luciana Pisani.
• Universidade Federal de São Paulo, Department of Biosciences - Santos (SP), Brazil.
• Rev Assoc Med Bras (1992). 2024 Jan 1; 70 (3): e20231167e20231167.

ObjectiveThe aim of this study was to analyze possible alterations (morphological and inflammatory) in the ocular cells of fetuses from mothers with insulin resistance exposed to saturated fatty acids through the period of pregnancy.MethodsWistar female rats were induced to develop insulin resistance before pregnancy. Fetuses' skulls were collected on the 20th day of intrauterine life. The rats were separated on the first day of management into two groups according to the diet applied: control group (C): diet containing soybean oil as a source of fat; and saturated fatty acid group (S): diet containing butter as a source of fat.ResultsHistological and immunohistochemical analyses have been conducted. The immunohistochemical analyses of interleukin 6, suppressor of cytokine signaling, 3 and signal transducer and activator of transcription 3 did not demonstrate alterations in the expression of proteins in the fetuses of mothers fed with a saturated fatty diet. Moreover, no histopathological changes were noticed between groups.ConclusionThe saturated fatty diet does not induce tissue changes or activate the Janus kinase/signal transducer and activator of transcription signaling pathway during eye development in the fetuses of mothers with insulin resistance.

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