• Hanna Gabriela da Cruz Alfaro, Gomes JuniorSaint ClairSC0000-0002-1554-943XFernandes Figueira Institute, Oswaldo Cruz Foundation, Department of Obstetrics and Fetal Medicine - Rio de Janeiro (RJ), Brazil., Renato Augusto Moreira de Sá, and Edward Araujo Júnior.
• Fernandes Figueira Institute, Oswaldo Cruz Foundation, Department of Obstetrics and Fetal Medicine - Rio de Janeiro (RJ), Brazil.
• Rev Assoc Med Bras (1992). 2024 Jan 1; 70 (3): e20231186e20231186.

ObjectiveThe aim of this study was to analyze the outcomes of newborns with Down syndrome admitted to three neonatal intensive care units in the city of Rio de Janeiro, Brazil.MethodsA retrospective cohort study was conducted by analyzing the medical records between 2014 and 2018 of newborns with Down syndrome admitted to three neonatal intensive care units. The following variables were analyzed: maternal and perinatal data, neonatal malformations, neonatal intensive care unit intercurrences, and outcomes.ResultsA total of 119 newborns with Down syndrome were recruited, and 112 were selected for analysis. The most common maternal age group was >35 years (72.07%), the most common type of delivery was cesarean section (83.93%), and the majority of cases were male (53.57%). The most common reasons for neonatal intensive care unit hospitalization were congenital heart disease (57.66%) and prematurity (23.21%). The most common form of feeding was a combination of human milk and formula (83.93%). The second most common malformation was duodenal atresia (9.82%). The most common complications during neonatal intensive care unit hospitalization were transient tachypnea of the newborn (63.39%), hypoglycemia (18.75%), pulmonary hypertension (7.14%), and sepsis (7.14%). The mean length of stay in the neonatal intensive care unit was 27 days. The most common outcome was discharge (82.14%). Furthermore, 12.50% of newborns were transferred to an external neonatal intensive care unit, and 6% died.ConclusionNewborns with Down syndrome are more likely to be admitted to the neonatal intensive care unit, and the length of hospital stay is longer due to complications related to congenital malformations common to this syndrome and prematurity.

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