• Chang Xu, Li-Yan Luo, Bi-Chen Wu, Niu Ding, Shi-Jie Jin, Jian-Bao Huang, and Yan-Ping Chen.
• Department of Respiratory, Hunan Children's Hospital, Changsha, China.
• Clinics (Sao Paulo). 2024 Jan 1; 79: 100361100361.

ObjectiveEarly diagnosis of Severity Mycoplasma Pneumoniae Pneumonia (SMPP) has been a worldwide concern in clinical practice. Two cytokines, soluble Triggering Receptor Expressed on Myeloid cells (sTREM-1) and Interferon-Inducible Protein-10 (IP-10), were proved to be implicated in bacterial infection diseases. However, the diagnostic value of sTREM-1 and IP-10 in MPP was poorly known. This study aimed to investigate the diagnostic value of sTREM-1 and IP-10 for SMPP.MethodsIn this prospective study, the authors enrolled 44 children with MPP, along with their clinical information. Blood samples were collected, and cytokine levels of sTREM-1 and IP-10 were detected with ELISA assay.ResultsSerum levels of sTREM-1 and IP-10 were positively correlated with the severity of MPP. In addition, sTREM-1 and IP-10 have significant potential in the diagnosis of SMPP with an Area Under Curve (AUC) of 0.8564 (p-value = 0.0001, 95% CI 0.7461 to 0.9668) and 0.8086 (p-value = 0.0002, 95% CI 0.6918 to 0.9254) respectively. Notably, the combined diagnostic value of sTREM-1 and IP-10 is up to 0.911 in children with SMPP (p-value < 0.001, 95% CI 0.830 to 0.993).ConclusionsSerum cytokine levels of sTREM-1 and IP-10 have a great potential diagnostic value in children with SMPP.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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