• Am. J. Med. Sci. · Sep 2024

    Review

    The future of chemical pleurodesis: A review of novel and investigational sclerosant agents.

    • Jonathan Glatt and Prarthna Chandar.
    • Thomas Jefferson University Hospital, Department of Pulmonary, Allergy, and Critical Care Medicine, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA. Electronic address: jglatt4@gmail.com.
    • Am. J. Med. Sci. 2024 Sep 1; 368 (3): 175181175-181.

    AbstractChemical pleurodesis is a technique in which an injurious and inflammatory substance is instilled into the pleural cavity to cause adhesion and fibrosis. It is commonly used in the management of recurrent malignant pleural effusions. Historically, many different types of sclerosants have been described, though only a few, including talc, the tetracycline derivatives, and anti-septic compounds such as silver nitrate and iodopovidone, have found their way into mainstream use. However, over the past several years, there has been increasing interest in alternative pleurodesis agents. In this review, we will explore future directions in the field, with an eye toward novel and investigational agents.Copyright © 2024. Published by Elsevier Inc.

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