• Indian J Med Res · Aug 2011

    Review

    An understanding of the genetic basis of asthma.

    • Mahdi Bijanzadeh, Padukudru A Mahesh, and Nallur B Ramachandra.
    • Department of Studies in Zoology, University of Mysore, Mysore, India.
    • Indian J Med Res. 2011 Aug 1; 134 (2): 149161149-61.

    AbstractAsthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment. This article reviews the current state of the genetics of asthma in six categories, viz. epidemiology, management, aetiology, family and twin studies, segregation and linkage studies, and candidate genes and single nucleotide polymorphisms (SNPs).

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