• Yongqiang Zhang, Shanshan Hu, Yiyao Deng, Zhi Yang, and Jing Yuan.
• Guizhou University of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China.
• Medicine (Baltimore). 2024 May 10; 103 (19): e38103e38103.

RationaleThrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy caused by reduced activity of the von Willebrand factor-cleaving protease (ADAMTS13), which can be life-threatening. The patient reported in this case study also had concurrent Sjögren syndrome and renal impairment, presenting multiple symptoms and posing a great challenge in treatment.Patient ConcernsA 25-year-old woman in the postpartum period visited the hospital due to indifference in consciousness for more than 1 day following cesarean section 8 days prior.DiagnosisNotable decreases were observed in platelets, hemoglobin, creatinine, and ADAMTS13 levels. After a consultative examination by an ophthalmologist, she was diagnosed with retinal hemorrhage in the right eye and dry eye syndrome in both eyes.InterventionsHaving been diagnosed with TTP with Sjögren syndrome and renal impairment, she received repeated treatments with plasmapheresis combined with rituximab.OutcomesFollowing treatment and during the follow-up period, the patient's platelet counts and bleeding symptoms significantly improved.LessonsTTP has a high mortality rate, and when combined with Sjögren syndrome and renal impairment, it poses an even greater challenge in treatment. However, after administering standard plasmapheresis combined with rituximab treatment, the treatment outcome is favorable.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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