• Intern Emerg Med · Aug 2024

    Prognostic role of serum albumin levels in patients with chronic heart failure.

    • Giuseppe Armentaro, Valentino Condoleo, Carlo Alberto Pastura, Maria Grasso, Angelo Frasca, Domenico Martire, Velia Cassano, Raffaele Maio, Leonilde Bonfrate, Daniele Pastori, Tiziana Montalcini, Francesco Andreozzi, Giorgio Sesti, Francesco Violi, and Angela Sciacqua.
    • Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100, Catanzaro, Italy.
    • Intern Emerg Med. 2024 Aug 1; 19 (5): 132313331323-1333.

    BackgroundHypoalbuminemia is common in heart failure (HF) patients; however, there are no data regarding the possible long-term prognostic role of serum albumin (SA) in the younger population with chronic HF without malnutrition. The aim of this study was to examine the long-term prognostic role of SA levels in predicting major adverse cardiac events (MACE) in middle-aged outpatients with chronic HF.MethodsIn the present retrospective analysis, 378 subjects with HF were enrolled. MACE (non-fatal ischemic stroke, non-fatal myocardial infarction, cardiac revascularization or coronary bypass surgery, and cardiovascular death), total mortality, and HF hospitalizations (hHF) occurrence were evaluated during a median follow-up of 6.1 years.ResultsIn all population, 152 patients had a SA value < 3.5 g/dL and 226 had a SA value ≥ 3.5 g/dL. In patients with SA ≥ 3.5 g/dL, the observed MACE were 2.1 events/100 patient-year; while in the group with a worse SA levels, there were 7.0 events/100 patient-year (p < 0.001). The multivariate analysis model confirmed that low levels of SA increase the risk of MACE by a factor of 3.1. In addition, the presence of ischemic heart disease, serum uric acid levels > 6.0 mg/dL, chronic kidney disease, and a 10-year age rise, increased the risk of MACE in study participants. Finally, patients with SA < 3.5 g/dl had a higher incidence of hHF (p < 0.001) and total mortality (p < 0.001) than patients with SA ≥ 3.5 g/dl.ConclusionsPatients with chronic HF that exhibits low SA levels show a higher risk of MACE, hHF and total mortality.© 2024. The Author(s).

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