• Mehmet Ozer, Pınar Tugce Ozer, Ibrahim Karaca, Suna Karaca, Alper Ileri, and Adnan Budak.
• Mehmet Ozer, Dept. of Obstetrics & Gynaecology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.
• Pak J Med Sci. 2024 May 1; 40 (5): 846850846-850.

ObjectiveTo compare the age-specific clinical features of molar pregnancy and to describe the risk factors associated with this situation.MethodThis retrospective case-control study was conducted at the Department of Obstetrics and Gynecology. Tepecik Education and Research Hospital, Izmir, Turkey. The participants included both adolescents (≤ 19 years) and adults with histologically confirmed hydatidiform moles in our institution between January 2015 and January 2022. The interventions and main outcome measures of this study involved evaluating the clinical and ultrasonographic features, as well as the risk factors, associated with molar pregnancies in adolescents.ResultsThis study of 137 patients with molar pregnancy found that adults had a higher incidence of partial molar pregnancy (20 patients versus seven patients) and lower beta-hCG levels than adolescents (176.890.71 mIU/ml versus 253.734.47 mIU/ml). Adolescents had a higher likelihood of hyperthyroidism (25.4% versus 9.2%). bleeding on admission (4.2% versus 1.51%),. longer hospital stays (5.44 ± 2.73 days versus 3.59 ± 3.08 days). Higher rates of uterine enlargement and postoperative bleeding (15.5% versus 1.5%). Adolescents also required more analgesia (97% versus 89.4%).ConclusionsAdolescents with Gestational trophoblastic diseases (GTD) may present with more severe symptoms compared to adults, which can lead to delayed diagnosis and treatment. Further research is needed to better understand the underlying mechanisms and risk factors for GTDs in this population. Increased awareness and education can help improve recognition and management of GTDs in adolescents and improve their overall health outcomes.Copyright: © Pakistan Journal of Medical Sciences.

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