• Huiying Huang, Shan Zhang, Hong Du, Yonghua Guo, and Hui Zheng.
• Huiying Huang, Department of Neurology, People's Hospital of Leshan, Leshan, Sichuan Province 614000, P.R. China.
• Pak J Med Sci. 2024 May 1; 40 (5): 891895891-895.

ObjectiveTo explore the effect of clopidogrel combined with aspirin in the treatment of acute progressive cerebral infarction (APCI).MethodsWe retrospectively analyzed the records of 190 patients with APCI admitted to Chengdu First People's Hospital from September 2020 to April 2023. The records were divided into an aspirin group (76 cases), a clopidogrel group (72 cases), and a clopidogrel plus aspirin group (42 cases) according to the treatment records. We compared the efficacy of the three treatment outcomes by analyzing the National Institutes of Health Stroke Scale (NIHSS) scores, and the levels of serum inflammatory factors (IL-8, TNF-α, and IL-1β), cone like protein-1 (VILIP-1), and caveolin-1 (Cav-1).ResultsThe total efficacy of the combination group (97.62%) was significantly higher than those of the aspirin group (73.68%) or the clopidogrel group (79.17%) (p<0.05). After treatment, the NIHSS scores, inflammatory factor levels, serum VILIP-1 and Cav-1 levels were significantly lower than those before treatment in the three groups, but all the levels were significantly lower in the combination group (all p<0.05).ConclusionsOur results indicate that compared with aspirin alone or clopidogrel alone, the combination of aspirin and clopidogrel is more effective for the treatment of APCI. The combination regimen effectively lowers serum inflammatory factors (IL-8, TNF-α, and IL-1β), as well as the VILIP-1 and Cav-1 levels.Copyright: © Pakistan Journal of Medical Sciences.

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