• Pak J Med Sci · May 2024

    Analysis of factors affecting the clinical efficacy and quality of life in the treatment of pediatric acute lymphoblastic leukemia.

    • Dan Liu and Yi-Fei Zhang.
    • Dan Liu, Department of Neonatology, Associate Chief Physician, Associate Professor, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei, China. The First Clinical Medical Collage of Yangtze University, Jingzhou 434000, Hubei, China. The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei, China.
    • Pak J Med Sci. 2024 May 1; 40 (5): 956961956-961.

    ObjectiveTo analyze the factors affecting the long-term clinical efficacy and quality of life in the treatment of pediatric acute lymphoblastic leukemia (ALL).MethodsThis is a retrospective study. One hundred children with ALL were collected before June, 2018 at The First Affiliated Hospital of Yangtze University and followed up for five years. Not only were their five-years survival rates analyzed, but univariate and multivariate analyses were also performed for factors that might affect their five-year survival rates. The MOS 36-Item Short Form of Health Survey (SF-36) was utilized to investigate the surviving children after five years in order to analyze the factors that may affect the quality of life of the children.ResultsThe five-years survival rate of one hundred children with ALL after treatment was 91.00% (91/100). Univariate and multivariate Logistic regression analyses were performed on the factors that may affect the long-term efficacy of pediatric ALL. The results showed that white blood cell count at first diagnosis, prednisone response test, treatment compliance and recurrence were independent risk factors for the long-term efficacy of pediatric ALL(p<0.05). The SF-36 survey of 91 surviving children after five years showed that prednisone response test and treatment compliance were independent risk factors affecting the quality of life of pediatric ALL(p<0.05).ConclusionIn the initial diagnosis of pediatric ALL, sufficient attention and control should be given to the factors that may affect the long-term clinical efficacy and quality of life, and appropriate treatment plans should be adopted. Meanwhile, the treatment compliance of children should be improved during treatment to improve the survival rate and quality of life of pediatric ALL.Copyright: © Pakistan Journal of Medical Sciences.

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