An Overview of Hereditary Angioedema for the Primary Care

Med. Clin. North Am. · Jul 2024

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An Overview of Hereditary Angioedema for the Primary Care Physician.

Hereditary angioedema is a rare autosomal dominant condition characterized by episodes of swelling of the upper airway, intestines, and skin. The disorder is characterized by deficiency in C1 esterase inhibitor (C1-INH) or a decrease in functional C1-INH. ⋯ Corticosteroids, epinephrine, and antihistamines are not effective for this form of angioedema. The high mortality in patients undiagnosed underscores a need for broader physician awareness to identify these patients and initiate therapy.

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- Arindam Sarkar, Crystal Nwagwu, and Timothy Craig.
- Department of Family and Community Medicine, Baylor College of Medicine, 1100 West 34th Street, Houston, TX 77007, USA. Electronic address: arindams@bcm.edu.
- Med. Clin. North Am. 2024 Jul 1; 108 (4): 747755747-755.
AbstractHereditary angioedema is a rare autosomal dominant condition characterized by episodes of swelling of the upper airway, intestines, and skin. The disorder is characterized by deficiency in C1 esterase inhibitor (C1-INH) or a decrease in functional C1-INH. Treatment options include on demand therapy (treatment of acute attacks), long-term prophylaxis, and short-term prophylaxis. Corticosteroids, epinephrine, and antihistamines are not effective for this form of angioedema. The high mortality in patients undiagnosed underscores a need for broader physician awareness to identify these patients and initiate therapy.Copyright © 2023 Elsevier Inc. All rights reserved.

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An Overview of Hereditary Angioedema for the Primary Care Physician.

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