• Shifeng Qiu, Tinghui Liu, Zijin Zhan, Xue Li, Xuewei Liu, Xiaoyu Xin, Junyan Lu, Lipei Wu, Li Wang, Kai Cui, and Jiancheng Xiu.
• Department of Cardiology, Southern Medical University, Nanfang Hospital, Guangzhou 510515, China.
• Postgrad Med J. 2024 May 25.

AbstractCardiovascular diseases (CVDs) present a significant global public health threat, contributing to a substantial number of cases involving morbidity and mortality. Therefore, the early and accurate detection of CVDs plays an indispensable role in enhancing patient outcomes. Decades of extensive research on electrocardiography at high frequencies have yielded a wealth of knowledge regarding alterations in the QRS complex during myocardial ischemia, as well as the methodologies to assess and quantify these changes. In recent years, the analysis of high-frequency QRS (HF-QRS) components has emerged as a promising non-invasive approach for diagnosing various cardiovascular conditions. Alterations in HF-QRS amplitude and morphology have demonstrated remarkable sensitivity as diagnostic indicators for myocardial ischemia, often surpassing measures of ST-T segment changes. This comprehensive review aims to provide an intricate overview of the current advancements, challenges, and prospects associated with HF-QRS analysis in the field of CVDs.© The Author(s) 2024. Published by Oxford University Press on behalf of Fellowship of Postgraduate Medicine.

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