• Gülçin Alp Avci, Ülkü İrem Yilmaz, and Emre Avci.
• University of Health Sciences, Faculty of Gulhane Dentistry, Department of Basic Medical Sciences - Ankara, Turkey.
• Rev Assoc Med Bras (1992). 2024 Jan 1; 70 (6): e20240226e20240226.

ObjectiveThe aim of this study was to reveal certain features (anti-tumor/microbial activities) of postbiotics and heat-inactivated paraprobiotics obtained from two different bacteria with determined probiotic properties, which are thought to contribute to human health.MethodsIn the study, Lactobacillus reuteri ENA31 and L. rhamnosus GAA6 strains were used. Supernatants of postbiotically active cultures were used. Paraprobiotics were obtained by exposing probiotic bacteria to high temperatures. The cytotoxic effects of probiotics, paraprobiotics, and postbiotics were evaluated by the MTT method. IL-1/-10/-12/-13, TNF-α, IFN-γ, and neopterin parameters were determined via the ELISA method in immunity studies.ResultsIt was detected that biotics had a cytotoxic effect on cancer cells with rising concentrations (paraprobioticConclusionOur study shows that biotics, which are widely used and beneficial to health, are also available for use in immunocompromised individuals. The resulting paraprobiotics and postbiotics will both increase the conscious use of probiotics and provide the opportunity for use in immunocompromised individuals.

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