• Dongdong Zang, Xuemei Yang, Hao Wang, Zhenxing Li, Yanjun Ma, Jianxi Liu, Xi Mei, Shupeng Li, Jinxing Feng, Xin Shi, and Zhen Tan.
• Department of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China.
• Clinics (Sao Paulo). 2024 Jan 1; 79: 100435100435.

ObjectiveThis study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.MethodsFour HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.ResultsIn the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.ConclusionThe results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short.Copyright © 2024. Published by Elsevier España, S.L.U.

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