• Yuanhui Xu, Lin Ma, Keliang Jia, Xiaoling Wu, and Chang Ge.
• From the Department of Anus and Intestine Surgery, Anorectal Surgery, The First Affiliated Hospital of Shandong, First Medical University, Shandong, China.
• Ann Saudi Med. 2024 Jul 1; 44 (4): 264271264-271.

IntroductionThis study aimed to determine the efficacy and safety of autologous PRP in anal fistula.MethodsThe search was done in electronic databases such as; PubMed, Scopus, Google Scholar, Embase, and Cochrane Library. The outcomes investigated in this study were the rate of improvement, the rate of recurrence, and the rate of fecal incontinence.ResultsCure, incontinence, and recurrence rates were 68% (95% CI, .60-.76), 27% (95% CI, .12-.46), and 18% (95% CI, .12-.26), respectively. The pooled improvement ratio in patients treated with PRP compared to control group was 1.35 times, which was statistically significant (pooled OR=1.35, 95% CI, 1.14-1.60, P<001). The pooled recurrence ratio in patients treated with PRP compared to control group was 1.17, which was not statistically significant (pooled OR=1.17, 95% CI, 0.44-3.11).DiscussionPlatelet-rich plasma is an effective method of healing people with anal fistula.

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