• Sumeyra Doluoglu, Omer Bayir, Bulent Ocal, Emel Cadalli Tatar, Mehmet Hakan Korkmaz, and Guleser Saylam.
• From the Department of Otorhinolaryngology, Ankara Etlik Integrated Health Campus, Ankara, Turkey.
• Ann Saudi Med. 2024 Jul 1; 44 (4): 213219213-219.

BackgroundIn the treatment of early stage laryngeal cancers, surgery (transoral laryngeal surgery (TOLS), open partial laryngeal surgery (OPLS) and radiotherapy (RT) are used.ObjectivesCompare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT.DesignRetrospective.SettingsTertiary training and research hospital.Patients And MethodsThe participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS).Main Outcome MeasuresThe effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers.Sample Size261.ResultsThe mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group (P=.034, .065, .269, .060, respectively).ConclusionsTOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups (P=.034).LimitationsRetrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.

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