• Med. Clin. North Am. · Sep 2024

    Review

    Novel Therapies for the Treatment of Cardiovascular Disease.

    • Abdul Aziz A Asbeutah and Zachary D Goldberger.
    • Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison Hospitals and Clinics, Madison, WI, USA. Electronic address: asbeutah@wisc.edu.
    • Med. Clin. North Am. 2024 Sep 1; 108 (5): 953964953-964.

    AbstractOver the last decade, randomized clinical trials of several pharmacologic agents have demonstrated a reduction in cardiovascular mortality and other important secondary outcomes. Angiotensin-Neprilysin Inhibitors and Sodium-Glucose Co-transporter 2 inhibitors have now become pillars in the treatment of heart failure. Ivabradine is a negative chronotropic agent used as an adjunctive therapy in patients with heart failure. Two new hypertension therapies, zilebresiran and aprocitentan, are currently in investigational stages. Finally, mavacamten has emerged as a pharmacologic treatment for hypertrophic obstructive cardiomyopathy. Practitioners must be familiar with the indications and side effects of newer therapies as they are now frequently prescribed.Copyright © 2024 Elsevier Inc. All rights reserved.

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