• Neuroscience · Aug 2024

    Understanding OLM interneurons: Characterization, circuitry, and significance in memory and navigation.

    • Beatriz Fernández-Arroyo, Sandra Jurado, and Juan Lerma.
    • Instituto de Neurociencias CSIC-UMH, 03550 San Juan de Alicante, Spain.
    • Neuroscience. 2024 Aug 7.

    AbstractUnderstanding the intricate mechanisms underlying memory formation and retention relies on unraveling how the hippocampus, a structure fundamental for memory acquisition, is organized. Within the complex hippocampal network, interneurons play a crucial role in orchestrating memory processes. Among these interneurons, Oriens-Lacunosum Moleculare (OLM) cells emerge as key regulators, governing the flow of information to CA1 pyramidal cells. In this review, we explore OLM interneurons in detail, describing their mechanisms and effects on memory processing, particularly in spatial and contextual memory tasks. Our aim is to provide a detailed understanding of how OLM interneurons contribute to the dynamic landscape of memory formation and retrieval.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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