• Yan-Chih Peng, Sih-Han Liao, Jia-Huei Tsai, Po-Ting Chen, Chin-Chen Chang, Jia-Horng Kao, and Kao-Lang Liu.
• Department of Medical Imaging, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
• J Formos Med Assoc. 2024 Aug 14.

Background/PurposeLymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare variant of intrahepatic cholangiocarcinoma (ICC). We aim to analyze the differences in the clinical and radiological features of LELCC and ICC.MethodsBetween January 2003 and December 2019, a total of 21 patients diagnosed with LELCC were retrospectively enrolled, and 84 patients with ICC were selected through propensity score matching by sex, age, and initial cancer stage. The clinical characteristics, pathological findings, and radiological features were analyzed. The differences in overall survival (OS) between LELCC and ICC were evaluated using the Kaplan-Meier method.ResultsThe serum carbohydrate antigen 19-9 (CA 19-9) level was higher in the ICC group than in the LELCC group (77.9 vs 30.0 U/mL, p = 0.004). Non-rim arterial phase hyperenhancement (47.1% vs 13.7%, p = 0.005) and portovenous washout (35.3% vs 4.1%, p = 0.001) were more frequently observed in the LELCC group than in the ICC group. Intrahepatic duct dilatation was a distinct feature of the ICC group. The 5-year OS rates in the LELCC and ICC groups were 69.3% and 58.2%, respectively (p = 0.047). The 5-year OS of patients with stages I and II LELCC between ICC were not significantly different (90.0% vs 83.4%, p = 0.464). However, the 5-year OS of patients with stages III and IV LELCC was more favorable than that of patients with ICC (29.2% vs 23.0%, p = 0.017).ConclusionsLELCC had a favorable outcome and several different clinicoradiological features compared with ICC.Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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