• Keisuke Yoshida, Takayuki Hasegawa, Takahiro Hakozaki, Tatsumi Yakushiji, Yuzo Iseki, Yuya Itakura, Shinju Obara, and Satoki Inoue.
• Department of Anesthesiology, Fukushima Medical University School of Medicine, 1 Hikariga-Oka, Fukushima, 960-1295, Fukushima, Japan. kei-y7of@fmu.ac.jp.
• J Clin Monit Comput. 2024 Aug 20.

AbstractThe high frequency variability index (HFVI)/analgesia nociception index (ANI) is purported to assess the balance between nociception and analgesia in patients under general anesthesia. This observational study investigated whether intraoperative HFVI/ANI correlates with postoperative pain in patients performed with nerve block under general anesthesia in video/robotic-assisted thoracoscopic surgery (VATS/RATS). We investigated whether maximum postoperative pain at rest and postoperative morphine consumption are associated with HFVI/ANI just before extubation, mean HFVI/ANI during anesthesia, the difference in HFVI/ANI between before and 5 min after the start of surgery, and the difference in HFVI/ANI between before and 5 min after the nerve block. Data obtained from 48 patients were analyzed. We found no significant association between HFVI/ANI just before extubation and postoperative Numerical Rating Scale (NRS) score. Receiver operating characteristic curve analysis revealed that moderate (NRS > 3) or severe (NRS > 7) postoperative pain could not be predicted by HFVI/ANI just before extubation. In addition, there were no associations between postoperative morphine consumption and HFVI/ANI at any time points. The present study demonstrated that it is difficult to predict the degree of postoperative pain in patients undergoing VATS/RATS under general anesthesia combined with peripheral nerve block, by using HFVI/ANI obtained at multiple time points during general anesthesia.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.

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