• Arankesh Mahadevan, Bhavin A Patel, Sashwath Srikanth, Raja Godasi, and Rupak Desai.
• Department of Neurology, University of Utah Health, Salt Lake City, UT, USA. Electronic address: arankeshmahadevan@gmail.com.
• Am. J. Med. Sci. 2024 Aug 19.

BackgroundEarly detection of carotid plaque (CP) can help reduce the burden of ASCVD in the general population. CP and triglyceride-glucose index (TyGi) are associated with insulin resistance.ObjectivesWe performed a meta-analysis exploring the association of TyGi levels with the incidence of CP.MethodsA systematic search of PubMed, Scopus, and Google Scholar till September 2023 reporting TyGi and CP identified 67 studies, of which 13 met our study criteria. TyGi was assessed both categorically and continuously. Binary random-effects models used for pooled odds ratios (OR) with 95 % confidence intervals (CI) and I2 statistic for heterogeneity.ResultsAnalyzed data from 163,792 patients with a mean age of 53 ± 8.9 years, primarily female (51.5 %). Common comorbidities were hypertension (42.4 %) followed by dyslipidemia (24.3 %). Multivariable analysis showed that high vs. low TyGi quartile was associated with a higher risk of CP with unadjusted OR (1.82, 95 % CI [1.5 - 2.21], p < 0.01; I² = 95.77, p < 0.01) and adjusted OR (1.3, 95 % CI [1.16 - 1.46], p < 0.01; I² = 79.71, p < 0.01). Increasing TyGi also had a higher risk of CP with unadjusted OR (1.53, 95 % CI [1.15 - 2.03], p < 0.01; I² = 98.48, p < 0.01) and adjusted OR (1.23, 95 % CI [1.11 - 1.35], p < 0.01; I² = 89.82, p < 0.01). The association was validated by sensitivity analysis.ConclusionOur study indicates a higher risk of CP in patients with higher TyGi scores, underscoring its significance as a predictor for carotid atherosclerosis.Copyright © 2024 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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