• Iulia Teodora Perva, Iulia Elena Simina, Renata Bende, Alexandru Cătălin Motofelea, Adela Chirita Emandi, Nicoleta Andreescu, Alexandra Sima, Adrian Vlad, Ioan Sporea, Cristian Zimbru, Paul Calin Tutac, Maria Puiu, and Mihai Dinu Niculescu.
• Department of Microscopic Morphology, Genetics Discipline, Center of Genomic Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq., 300041 Timisoara, Romania.
• Medicina (Kaunas). 2024 Aug 21; 60 (8).

AbstractBackground and Objectives: The goal of this study was to assess the impact of supplementation with a combination of nutrients on metabolic-dysfunction-associated steatotic liver disease (MASLD)-related liver parameters, and other parameters related to metabolic syndrome in adults with obesity. These measurements included anthropometric and lipid profiling, and FibroScan technology (controlled attenuation parameter (CAP) and transient elastography (TE) values). Materials and Methods: A double-blind, placebo-controlled pilot clinical trial was conducted over a three-month treatment period. Adults with metabolic syndrome and obesity were allocated to receive either a cocktail of nutrients with defined daily dosages (5-MTHF, betaine, alpha-linolenic acid, eicosapentaenoic acid, choline bitartrate, docosahexaenoic acid, and vitamin B12) or a placebo. The participants were evaluated at the start and the end of the three-month treatment period. Results: A total of 155 participants entered the study, comprising 84 in the treatment group and 71 in the placebo group. The administration of the nutritional supplement resulted in a notable reduction in both CAP and TE scores when compared to the placebo group. The treatment group exhibited a mean reduction in CAP of 4% (p < 0.05) and a mean reduction in TE of 7.8% (p < 0.05), indicative of a decline in liver fat content and fibrosis. Conclusions: The supplementation over a period of three months led to a significant amelioration of liver fibrosis and steatosis parameters in adults with metabolic syndrome and obesity. These findings suggest that this supplementation regimen could be a beneficial adjunct therapy for improving liver health in adults with obesity-induced MASLD.

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