• Pedro Adolpho de Menezes Pacheco Serio, Daniela Marques Saccaro, de GouvêaAna Carolina Ribeiro ChavesACRCCentro de Oncologia e Doenças Autoimune (COE), São Jose dos Campos, SP, Brazil., Giselly Encinas, Simone Maistro, Gláucia Fernanda de Lima Pereira, Vinícius Marques Rocha, Larissa Dias de Souza, Viviane Jennifer da Silva, Maria Lucia Hirata Katayama, and Maria Aparecida Azevedo Koike Folgueira.
• Comprehensive Center for Precision Oncology (C2PO), Centro de Investigação Translacional em Oncologia (CTO), Departamento de Radiologia e Oncologia, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. Electronic address: pedro.serio@usp.br.
• Clinics (Sao Paulo). 2024 Jan 1; 79: 100479100479.

ObjectivesTo identify somatic mutations in tumors from young women with triple-negative or luminal breast cancer, through targeted sequencing and to explore the cancer driver potential of these gene variants.MethodsA customized gene panel was assembled based on data from previous sequencing studies of breast cancer from young women. Triple-negative and luminal tumors and paired blood samples from young breast cancer patients were sequenced, and identified gene variants were searched for their driver potential, in databases and literature. Additionally, the authors performed an exploratory analysis using large, curated databases to evaluate the frequency of somatic mutations in this gene panel in tumors stratified by age groups (every 10 years).ResultsA total of 28 young women had their tumoral tissue and blood samples sequenced. Using a customized panel of 64 genes, the authors could detect cancer drivers in 11/12 (91.7 %) TNBC samples and 11/16 (68.7 %) luminal samples. Among TNBC patients, the most frequent cancer driver was TP53, followed by NF1, NOTCH1 and PTPN13. In luminal samples, PIK3CA and GATA3 were the main cancer drivers, and other drivers were GRHL2 and SMURF2. CACNA1E was involved in both TN and luminal BC. The exploratory analysis also indicated a role for SMURF2 in luminal BC development in young patients.ConclusionsThe data further indicates that some cancer drivers are more common in a specific breast cancer subtype from young patients, such as TP53 in TNBC and PIK3CA and GATA3 in luminal samples. These results also provide additional evidence that some genes not considered classical cancer-causing genes, such as CACNA1E, GRHL2 and SMURF2 might be cancer drivers in this age group.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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