• Clinics · Jan 2024

    Serum progesterone, glycosylated hemoglobin and insulin levels with the risk of premature rupture of membranes in gestational diabetes mellitus.

    • LiRong Zhou, XueSong Xiong, and LianHua Chen.
    • Department of Endocrinology and Metabolism, Affiliated Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan City, Hubei Province, China.
    • Clinics (Sao Paulo). 2024 Jan 1; 79: 100461100461.

    ObjectiveTo discuss the correlation between serum progesterone, glycosylated Hemoglobin (HbA1c), and insulin levels in pregnant women with Gestational Diabetes Mellitus (GDM) and the risk of Premature Rupture of Membranes (PROM).MethodsA retrospective analysis was conducted on 52 patients diagnosed with GDM who also presented with PROM (Observation group) and compared with 89 patients diagnosed with GDM but not complicated with PROM (Control group). Progesterone, insulin, and HbA1c were detected. Risk factors for PROM in GDM patients were analyzed.ResultsThe observation group had higher HbA1c and fasting blood glucose levels. Poor blood glucose control and GWG are risk factors for PROM in GDM patients. PROM increases adverse pregnancy outcomes in GDM. HbA1c, insulin, and HOMA-IR can predict the risk of PROM in GDM.ConclusionsThe effective prediction of preterm PROM can be achieved through the monitoring of serum HbA1c, insulin levels, and insulin resistance in patients with GDM.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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