• JNMA J Nepal Med Assoc · Feb 2024

    Case Reports

    Hypokalemia Induced Partial Nephrogenic Diabetes Insipidus: A Case Report.

    • Anil Nepali, Prakriti Adhikari, Amit Shah, Shailes Paudel, and Prakriti Bhandari.
    • Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
    • JNMA J Nepal Med Assoc. 2024 Feb 29; 62 (271): 217219217-219.

    AbstractDiabetes insipidus is a condition characterised by a large volume of diluted urine production and increased thirst. In this case report, a 49-year-old gentleman presented with 3 months of polyuria and polydipsia. He had a repeated history of hypokalemia. On the evaluation of polyuria and polydipsia, he was diagnosed with partial nephrogenic diabetes insipidus based on his inability to concentrate urine after a water deprivation test and his less than 50% response to exogenous desmopressin. On the evaluation of recurrent hypokalemia, the investigation reports met biochemical criteria for the diagnosis of Gitelman syndrome. He was encouraged to increase his fluid intake as required, and potassium chloride supplementation relieved his symptoms. This case report demonstrates the reversibility of nephrogenic diabetes insipidus with a correction of hypokalemia.

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