• Ulus Travma Acil Cerrahi Derg · Oct 2024

    Is there any effect of lidocaine on ischemia/reperfusion injury in testicular torsion? An experimental study.

    • Vildan Kölükçü, BaltaMehtap GürlerMGDepartment of Anesthesiology and Reanimation, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat-Türkiye., Hakan Tapar, Tugba Karaman, Serkan Karaman, Velid Unsal, Fikret Gevrek, Kenan Yalçın, and Fatih Fırat.
    • Department of Anesthesiology and Reanimation, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat-Türkiye.
    • Ulus Travma Acil Cerrahi Derg. 2024 Oct 1; 30 (10): 708714708-714.

    BackgroundThis experimental study aimed to evaluate the potential protective effects of lidocaine on ischemia-reperfusion injury resulting from testicular torsion/detorsion in rats.MethodsA total of 18 male rats were randomized into three groups. Group 1 served as the control group. Group 2 was designed to evaluate testicular ischemia-reperfusion injury using a torsion/detorsion model. In Group 3, the treatment group, a similar ischemia-reperfusion model was used as in Group 2. Additionally, lidocaine at a dose of 15 mg/kg was administered intraperitoneally five minutes before reperfusion. Blood biochemical analyses and testicular histopathological evaluations were conducted.ResultsBlood biochemical analysis showed that malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly higher in Group 2 compared to the other groups (p<0.001 and p=0.008, respectively). Proinflammatory cytokine levels, including interleu-kin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), were lower in Group 3 than in Group 2 (p<0.001, p=0.007, and p=0.026, respectively). Antioxidant enzyme activities, including glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.005 and p=0.025, respectively). Histopathological evaluations revealed significant improvements in all testicular damage scores, including hemorrhage, edema, vasocongestion, and inflammation in Group 3 compared to Group 2 (p=0.015, p=0.035, p=0.015, and p=0.034, respectively). Additionally, there was a notable improvement in the Johnsen score in Group 3 compared to Group 2 (p=0.034).ConclusionLidocaine, an effective local anesthetic, significantly alleviates the effects of testicular ischemia-reperfusion injury.

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