• Efthalia Angelopoulou, Vasilios C Constantinides, Evangelos Koumasopoulos, Evangelia Stanitsa, Efstratios-Stylianos Pyrgelis, Andreas Kyrozis, Elisabeth Kapaki, Leonidas Stefanis, and Sokratis G Papageorgiou.
• 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
• Curr Med Res Opin. 2024 Oct 1; 40 (10): 173717401737-1740.

IntroductionCorticobasal syndrome (CBS) is a rare form of atypical parkinsonism, most commonly caused by neurodegenerative disorders. Autoimmune underlying conditions are extremely rare, and anti-Yo antibody-associated CBS has not been reported yet.Case ReportHerein, we describe a case of a 68-year-old woman presenting with progressive dysarthria, gait instability and difficulty using her left hand with subacute deterioration during the last 3 months. Neurological examination revealed asymmetrical parkinsonism and pyramidal syndrome, reflex myoclonus and dystonia of her left upper limb, accompanied by apraxia of her left lower limb, fulfilling the criteria for possible CBS. Neuroimaging showed asymmetric frontoparietal atrophy, while cerebrospinal fluid and dopamine transporter imaging were normal. Prior to our evaluation, antineuronal autoantibody testing indicated positive anti-Yo antibodies. There was mild improvement after second IVIG cycle, and further investigation revealed no tumor.ConclusionAlthough autoimmune etiology of this case cannot be certain, it highlights the potential expansion of the clinical spectrum of anti-Yo-associated paraneoplastic syndrome.

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