• Jessica Ailani, Motomori Lewis, Feng Dai, Aaron Jenkins, Jessica Cirillo, Karin Hygge Blakeman, Lucy Abraham, and Joshua Brown.
• Department of Neurology, Medstar Georgetown University Hospital, Washington, DC, USA.
• Curr Med Res Opin. 2024 Nov 1; 40 (11): 191319201913-1920.

ObjectiveTo assess tablet utilization patterns and describe pre-treatment characteristics among new users of rimegepant.BackgroundRimegepant is the only oral calcitonin gene-related peptide antagonist approved in the United States for both the acute and preventive treatment of migraine.MethodsWe conducted a retrospective cohort study of people with migraine who initiated treatment with rimegepant using two US commercial claims databases (MarketScan and Optum). Patients (≥18 years old) with migraine who newly initiated rimegepant were included. Patients were stratified into two groups representing acute (quantity = 8) and prevention (quantity = 15 or 16) use cohorts. Baseline characteristics and medication use history were assessed on index and during the 365-day pre-index period. Rimegepant utilization periods were calculated based on days supplied and varying approaches to define use periods. Tablet quantity per 30 days was reported separately for both acute and prevention cohorts.ResultsIn MarketScan, a total of 14,037 rimegepant users were identified; 11,195 (79.8%) in the acute group and 1,880 (13.4%) in the prevention group. Rimegepant utilization for acute use was 4.9 ± 2.1 tablets per 30 days and for preventive use was 13.1 ± 7.7 tablets per 30 days. There was high baseline prevalence of triptan contraindications, warnings, and high cardiovascular risk, with a combined 46.2% meeting one or more of these criteria. Acute medication overuse was also common (25.1%) prior to rimegepant initiation. Results were consistent in the Optum database.ConclusionOur analysis provides the first real-world data available on tablet utilization and characteristics of new users of rimegepant.

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