• Arch Med Sci · Jan 2024

    Sanguiin inhibits cerebral hemorrhage in rats by protecting the blood-brain barrier.

    • Liguo Zhang, Jing Li, Yisong Zhang, and Hengzhu Zhang.
    • Department of Neurosurgery, The Dalian School of Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China.
    • Arch Med Sci. 2024 Jan 1; 20 (4): 134513481345-1348.

    IntroductionThe aim of the study was to observe the effect of Sanguiin on cerebral edema and behavior in a rat cerebral hemorrhage model.MethodsA rat collagenase-induced cerebral hemorrhage model was established to detect the effects of drugs on brain edema.ResultsThrough magnetic resonance imaging (MRI) analysis and brain weight content (BWC) determination, it was found that Sanguiin could significantly reduce the brain swelling index and BWC of the affected hemisphere after cerebral hemorrhage.ConclusionsSanguiin can significantly improve the neurological deficits in rats with cerebral hemorrhage, and down-regulate the expression of MMP-9 after cerebral hemorrhage, suggesting that Sanguiin has a certain protective effect on the blood-brain barrier after cerebral hemorrhage.Copyright: © 2024 Termedia & Banach.

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