• B W Mol, P J Hajenius, S Engelsbel, W M Ankum, F van der Veen, D J Hemrika, and P M Bossuyt.
• Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands. b.w.mol@amc.uva.nl
• Fertil. Steril. 1999 Jan 1;71(1):167-73.

ObjectiveTo evaluate the ability of noninvasive diagnostic tools to predict tubal rupture and active bleeding in patients with tubal pregnancy.DesignProspective cohort study.SettingTwo large teaching hospitals in Amsterdam, The Netherlands.Patient(S)Consecutively seen patients with suspected tubal pregnancy who were scheduled to undergo confirmative laparoscopy.Main Outcome Measure(S)Tubal rupture and/or active bleeding confirmed at laparoscopy.Result(S)Sixty-five (23%) of 288 patients had tubal rupture and/or active bleeding at laparoscopy. Abdominal pain, rebound tenderness on abdominal examination, fluid in the pouch of Douglas at transvaginal ultrasound examination, and a low serum hemoglobin level were independent predictors of tubal rupture and/or active bleeding. Pregnancy achieved with the use of IVF-ET and the presence of an ectopic gestational sac or an ectopic mass at ultrasound examination reduced the risk of tubal rupture. Abdominal pain was the most sensitive predictor, with a sensitivity of 95%.Conclusion(S)Because the nonsurgical management of tubal pregnancy should be used only when the risk of tubal rupture and/or active bleeding is low, it can be safely applied in only a limited number of patients.

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