• Lung · Apr 2013

    Review

    Therapeutic potential of growth factors in pulmonary emphysematous condition.

    • Jai Prakash Muyal, Vandana Muyal, Sudhir Kotnala, Dhananjay Kumar, and Harsh Bhardwaj.
    • Department of Biotechnology, School of Biotechnology, Gautam Buddha University, Greater Noida, 201308, India. jmuyal@gbu.ac.in
    • Lung. 2013 Apr 1;191(2):147-63.

    AbstractPulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease (COPD), which is characterized by progressive destruction of alveolar parenchyma with persistent inflammation of the small airways. Such destruction in the distal respiratory tract is irreversible and irreparable. All-trans-retinoic acid was suggested as a novel therapy for regeneration of lost alveoli in emphysema. However, profound discrepancies were evident between studies. At present, no effective therapeutic options are available that allow for the regeneration of lost alveoli in emphysematous human lungs. Recently, some reports on rodent's models have suggested the beneficial effects of various growth factors toward alveolar maintenance and repair processes.

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