• Heart Lung · Mar 2010

    Case Reports

    Persistent methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia due to a linezolid "tolerant" strain.

    • Burke A Cunha, Sara Nausheen, and Paul Schoch.
    • Divisions of Infectious Disease, General Internal Medicine, and Cardiology, Winthrop-University Hospital, Mineola, New York 11501, USA.
    • Heart Lung. 2010 Mar 1;39(2):173-5.

    AbstractAntibiotic "tolerance" is a rare cause of antibiotic failure. Antibiotic "tolerance" is defined as an minimal bactericidal concentration (MBC) 32x the minimal inhibitory concentration (MIC) of the isolate. Although susceptibility testing based on the MIC suggests susceptibility of "tolerant" strains, bactericidal concentrations are often beyond achievable serum levels and therapeutic failure may result. We present a case of persistent methicillin-sensitive S. aureus (MSSA) bacteremia due to a linezolid "tolerant" strain unresponsive to daptomycin therapy. We believe this is the first report of persistent MSSA bacteremia due to a linezolid "tolerant" strain.Copyright 2010 Elsevier Inc. All rights reserved.

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