• Headache · Jul 2006

    Case Reports

    Melatonin responsive hemicrania continua.

    • Todd D Rozen.
    • Michigan Head-Pain and Neurological Institute, Ann Arbor, MI 48104, USA.
    • Headache. 2006 Jul 1;46(7):1203-4.

    AbstractHemicrania continua is one of the indomethacin-responsive headache syndromes. There are very few effective alternative therapies for hemicrania continua, thus patients may require daily indomethacin for years. The risks of long-term indomethacin include gastrointestinal and renal dysfunction. Melatonin is a pineal hormone with a chemical structure very similar to indomethacin. Recently, melatonin was shown to be effective for primary stabbing headache, another indomethacin-responsive syndrome. Three cases of melatonin responsive hemicrania continua are now reported.

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