• Masui · Sep 2013

    Review

    [Regional anesthesia and cancer immunology].

    • Toru Igarashi, Katsuya Mori, Kei Inoue, Takeshi Suzuki, and Hiroshi Morisaki.
    • Department of Anesthesiology, Keio University School of Medicine, Tokyo 160-8582.
    • Masui. 2013 Sep 1;62(9):1097-105.

    AbstractRegional anesthesia has been widely applied as an excellent method for perioperative analgesia. Recent studies suggested that regional anesthesia is a promising approach to minimize the risk of surgical site infection and postoperative cancer recurrence, subsequently providing the benefits to the long-term outcome. In particular, it is of great interest that regional anesthesia might be able to reduce cancer recurrence. In cancer patients, innate immunity against cancer could be depressed, resulting in the predisposition to evoke metastasis. Besides, during the perioperative periods, tumor immunity is significantly depressed due to surgical pain, activation of sympathetic nervous system, inflammatory responses, and others. In this review article, we discuss the tumor immunity during the perioperative period, with focus on the alterations of tumor immunity and regional anesthesia.

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