• J. Intern. Med. · Jan 2006

    Modelling and imaging cardiac repolarization abnormalities.

    • Y Rudy.
    • Cardiac Bioelectricity and Arrhythmia Center (CBAC), Washington University in St Louis, St Louis, MO 63130-4899, USA. rudy@wustl.edu
    • J. Intern. Med. 2006 Jan 1;259(1):91-106.

    AbstractRepolarization abnormalities, including those induced by the congenital or acquired long QT (LQT) syndrome, provide a substrate for life-threatening cardiac arrhythmias. In this article, we use computational biology to link HERG mutations mechanistically to the resulting abnormalities of the whole-cell action potential. We study how the kinetic properties of I(Ks) (the slow delayed rectifier) that are conferred by molecular subunit interactions, facilitate its role in repolarization and 'repolarization reserve'. A new noninvasive imaging modality (electrocardiographic imaging) is shown to image cardiac repolarization on the epicardial surface, suggesting its possible role in risk stratification, diagnosis and treatment of LQT syndrome.

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