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Editorial Comment
The host response to infection: advancing a novel diagnostic paradigm.
- Geoffrey S Ginsburg and Christopher W Woods.
- Crit Care. 2012 Jan 1;16(6):168.
AbstractCapturing the host response by using genomic technologies such as transcriptional profiling provides a new paradigm for classifying and diagnosing infectious disease and for potentially distinguishing infection from other causes of serious respiratory illness. This strategy has been used to define a blood-based RNA signature as a classifier for pandemic H1N1 influenza infection that is distinct from bacterial pneumonia and other inflammatory causes of respiratory disease. To realize the full potential of this approach as a diagnostic test will require additional independent validation of the results and studies to examine the specificity of this signature for viral versus bacterial infection or co-infection.
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