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Pediatr. Clin. North Am. · Oct 2012
The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children.
- Enno D Wildschut, Annewil van Saet, Pavla Pokorna, Maurice J Ahsman, John N Van den Anker, and Dick Tibboel.
- Department of Pediatric Surgery, Intensive Care, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. e.wildschut@erasmusmc.nl
- Pediatr. Clin. North Am. 2012 Oct 1;59(5):1183-204.
AbstractExtracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled trials that show its efficacy. Hypothermia is frequently used in children and neonates during cardiopulmonary bypass (CPB). By combining data from pharmacokinetic studies in children on ECMO and CPB and during hypothermia, this review elucidates the possible effects of hypothermia during ECMO on drug disposition.Copyright © 2012 Elsevier Inc. All rights reserved.
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