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- L Spikes, T Williamson, and L Satterwhite.
- University of Kansas Medical Center, Kansas City, Kansas, USA. LSpikes@kumc.edu.
- Drugs Today. 2014 Jun 1;50(6):401-6.
AbstractMacitentan is a novel, dual endothelin receptor antagonist recently approved for the treatment of WHO Group I pulmonary arterial hypertension. Its pharmacologic mechanism of action as well as the pharmacokinetics, pharmacodynamics and potential drug-drug interactions have been demonstrated in multiple phase I and II trials. The pivotal randomized, placebo-controlled, event-driven clinical trial revealed a significant reduction in morbidity. The most common adverse events were rarely clinically significant, nor did they result in a high rate of discontinuation. Of note, macitentan is contraindicated in pregnant women due to embryo-fetal toxicity.Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.
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