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- Chun Yang, Bin Zhu, Jiang Shen, Tingting Hu, Zhangjun Li, and Tao Hong.
- Department of Anesthesiology, The Third Affiliated Hospital of SooChow University, Changzhou, PR China.
- Med. Hypotheses. 2013 Sep 1;81(3):487-8.
AbstractSeveral lines of evidence have indicated that rapamycin acts as an inhibitor of mammalian target of rapamycin (mTOR) and this produces therapeutic benefits as a treatment for Alzheimer's disease (AD) by activating an autophagic pathway. Similarly, postoperative cognitive dysfunction (POCD) is a decline in cognitive function for weeks or months after surgery. POCD and AD are both characterized by cognitive dysfunction, and more importantly, are both related to aging. We therefore hypothesized that rapamycin may have a therapeutic effect to relieve POCD. Inhibition of mTOR induces autophagic effect, thereby leading to a slower aging process, so this would be a novel target for the prevention and treatment of POCD.Copyright © 2013 Elsevier Ltd. All rights reserved.
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