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- Netta Levin, John Moshe Gomori, and Tali Siegal.
- Leslie & Michael Gaffin Center for Neuro-Oncology and the Neuro-Imaging Unit, Hadassah-Hebrew University Hospital, Jerusalem, Israel. imbar_l@netvision.net.il
- Neurology. 2004 Jul 27;63(2):354-6.
AbstractThe optimal therapy for gliomatosis cerebri is unclear, and the rate of response to chemotherapy is not known. Eleven radiotherapy-naive patients received a median number of 10 treatment cycles of temozolomide. An objective response was documented in 45%, and the median time to tumor progression was 13 months with a progression-free survival of 55% at 12 months. These results indicate that radiotherapy to extensive brain regions can be deferred until progressive disease is observed.
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