• Clinical pediatrics · Jul 2001

    Randomized Controlled Trial Comparative Study Clinical Trial

    A randomized, blinded comparison of chloral hydrate and midazolam sedation in children undergoing echocardiography.

    • D S Wheeler, R A Jensen, and W B Poss.
    • Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH, USA.
    • Clin Pediatr (Phila). 2001 Jul 1;40(7):381-7.

    AbstractThe objective of this prospective, randomized, and blinded study was to compare the use of chloral hydrate versus oral midazolam sedation in children undergoing echocardiography. No adverse effects (nausea, vomiting, paradoxical agitation, or significant deviations from baseline vital signs) were noted with either medication. No differences were noted in onset of sedation between the 2 groups, however, the time to complete recovery was significantly shorter with midazolam than with chloral hydrate. The children in the chloral hydrate group had a significantly deeper level of sedation and were more likely to receive a more nearly comprehensive echocardiographic evalation.

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