Neurodevelopmental implications of the use of sedation and

Clinics in perinatology · Sep 2013

Review

Neurodevelopmental implications of the use of sedation and analgesia in neonates.

Laboratory studies have shown that general anesthetics may cause accelerated apoptosis and other adverse morphologic changes in neurons of the developing brain. The mechanism may be related to the neuronal quiescence or inactivity associated with anesthetic exposure. Few data exist on how brief anesthetic exposure may affect neurodevelopment in the newborn. Good evidence however shows that untreated pain and stress have an adverse effect on neurodevelopment, and therefore, at this stage, providing effective analgesia, sedation, and anesthesia would seem to be more important than concern over neurotoxicity.

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- Andrew Davidson and Randall P Flick.
- Department of Anaesthesia and Pain Management, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia. andrew.davidson@rch.org.au
- Clin Perinatol. 2013 Sep 1;40(3):559-73.
AbstractLaboratory studies have shown that general anesthetics may cause accelerated apoptosis and other adverse morphologic changes in neurons of the developing brain. The mechanism may be related to the neuronal quiescence or inactivity associated with anesthetic exposure. Few data exist on how brief anesthetic exposure may affect neurodevelopment in the newborn. Good evidence however shows that untreated pain and stress have an adverse effect on neurodevelopment, and therefore, at this stage, providing effective analgesia, sedation, and anesthesia would seem to be more important than concern over neurotoxicity.Copyright © 2013 Elsevier Inc. All rights reserved.

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Neurodevelopmental implications of the use of sedation and analgesia in neonates.

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