• Curr Opin Crit Care · Jun 2013

    Review

    Is there a role for adrenaline during cardiopulmonary resuscitation?

    • Gavin D Perkins.
    • Royal United Hospital, Bath, UK. jerry.nolan@nhs.net
    • Curr Opin Crit Care. 2013 Jun 1;19(3):169-74.

    Purpose Of ReviewTo critically evaluate the recent data on the influence adrenaline has on outcome from cardiopulmonary resuscitation.Recent FindingsTwo prospective controlled trials in out-of-hospital cardiac arrest (OHCA) have indicated that adrenaline increases the rate of return of spontaneous circulation (ROSC), but neither was sufficiently powered to determine the long-term outcomes. Several observational studies document higher ROSC rates in patients receiving adrenaline after OHCA, but these also document an association between receiving adrenaline and worse long-term outcomes.SummaryAppropriately powered prospective, placebo-controlled trials of adrenaline in cardiac arrest are essential if the role of this drug is to be defined reliably.

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