• Ruwan Kiringoda, Audrey E Thurm, Matthew E Hirschtritt, Deloris Koziol, Robert Wesley, Susan E Swedo, Naomi P O'Grady, and Zenaide M N Quezado.
• Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
• Arch Pediatr Adolesc Med. 2010 Jun 1;164(6):554-60.

ObjectivesTo quantify the incidence of adverse events associated with anesthesia given for research-driven imaging studies and to identify risk factors for those events in pediatric research subjects.DesignRetrospective cohort study.SettingNational Institutes of Health Clinical Center.ParticipantsChildren and adolescents enrolled in clinical research protocols who required anesthesia for research-related imaging studies from January 2000 to September 2008.InterventionPropofol sedation/anesthesia.Main Outcome MeasureThe occurrence of respiratory, cardiovascular, and all anesthesia-related adverse events that required intervention while receiving anesthetics for research-driven imaging studies and other noninvasive procedures.ResultsWe identified 607 children who received 1480 propofol anesthetic procedures for imaging studies. Seventy percent of anesthetics were given to subjects with severe diseases and significant disabilities (American Society of Anesthesiologists Physical Status [ASA] III). Anesthesia had a mean (SD) duration of 115 (55) minutes, and in 12.5% of procedures, an airway device was necessary. There were 98 notable respiratory, cardiovascular, and other events in 79 anesthetic procedures, a rate of 534 per 10 000 anesthetic procedures with 1 or more adverse events. There was no long-lasting morbidity or mortality. The ASA classification (odds ratio [OR], 2.92; 95% confidence interval [CI], 1.24-6.88), anesthetic effect duration (OR, 1.46; 95% CI, 1.25-1.70), and presence of airway abnormalities (OR, 4.41; 95% CI, 1.60-12.12) were independently associated with adverse events during anesthetic use.ConclusionIn our clinical research sample of high-risk children who received sedation/anesthesia by an anesthesiologist, we observed a low incidence of adverse events and no long-term complications. Risk factors for adverse events included higher ASA classification, increasing anesthetic duration, and presence of airway abnormalities.

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