• F M Brunkhorst and K Reinhart.
• Paul-Martini-FG Klinische Sepsisforschung, Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, 07743, Jena, Deutschland. frank.brunkhorst@med.uni-jena.de
• Internist (Berl). 2009 Jul 1;50(7):817-24, 826-7.

AbstractSevere sepsis and septic shock have an increasing incidence but an unchanged mortality. It has been demonstrated that the time until the start of supportive therapy affects the progress of multiorgan failure and patient outcome. Early goal-directed therapy guided by central venous oxygen saturation is associated with a significant reduction in mortality, as is the use of lung-protective mechanical ventilation and recombinant activated protein C (rhAPC) in eligible patients. The use of starches for volume resuscitation, low-dose dopamine and hydrocortison as well as an intensive insulin protocol for restoration of euglycemia is not recommended. The German Competence Network Sepsis (SepNet) is currently studying further relevant questions.

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