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Intensive care medicine · Dec 2009
Frequency and clinical impact of preserved bispectral index activity during deep sedation in mechanically ventilated ICU patients.
- Pierre Trouiller, Pascal Fangio, Catherine Paugam-Burtz, Corinne Appéré-de-Vecchi, Paul Merckx, Nicolas Louvet, Sebastian Pease, Hervé Outin, Jean Mantz, and Bernard De Jonghe.
- Department of Anaesthesiology and Critical Care, Beaujon University Hospital, Clichy, France.
- Intensive Care Med. 2009 Dec 1;35(12):2096-104.
ObjectiveDespite an overall correlation between the bispectral index of the EEG (BIS) and clinical sedation assessment, unexpectedly high BIS values can be observed at deep sedation levels. We assessed the frequency, interindividual variability and clinical impact of high BIS values during clinically deep sedation.Design And SettingProspective observational study in two university-affiliated intensive care units.PatientsSixty-two mechanically ventilated patients requiring intravenous sedation and analgesia for >or=24 h.Measurements And Main ResultsPaired measurements of BIS and sedation measured on the adaptation to intensive care environment (ATICE) score were obtained every 3 h until awakening. A paired measurement with BIS >60 at deep sedation (ATICE Awakeness
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