• Rev Med Brux · Sep 2006

    [Pregabalin (Lyrica) and neuropathic pain syndromes].

    • J Jacquy, D Lossignol, and J Sternon.
    • Service de Neurologie, C.H.U. de Charleroi.
    • Rev Med Brux. 2006 Sep 1;27(5):445-50.

    AbstractPregabalin is a novel central nervous system (CNS) drug with no interaction at benzodiazepine or GABA receptor. Its mechanism of action is correlated with its high affinity for the alpha/delta submit of the voltage-dependant CNS calcium channel. Pregabalin is rapidly absorbed with at least 90% bioavailable irrespective of dose, does not bind to plasma proteins and is excreted virtually unchanged by the kidneys. Pharmacokinetics are linear and predictable across the therapeutic dose range (150-600 mg/ day). Pregabalin is indicated, like gabapentin, in the treatment of neuropathic pain syndromes like post-herpetic neuralgia (PHN) and diabetic polyneuropathy (DPN). Efficacy in other neuropathic pain syndromes need further investigations. This paper emphasizes advantages and disadvantages on a clinical point of view.

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