• Neurology · Oct 2006

    Randomized Controlled Trial

    Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.

    • J M Leung, L P Sands, M Rico, K L Petersen, M C Rowbotham, J B Dahl, C Ames, D Chou, and P Weinstein.
    • Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143-0648, USA. leungj@anesthesia.ucsf.edu
    • Neurology. 2006 Oct 10;67(7):1251-3.

    AbstractIn this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

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