• Neuroscience bulletin · Oct 2012

    Sevoflurane exposure in 7-day-old rats affects neurogenesis, neurodegeneration and neurocognitive function.

    • Fang Fang, Zhanggang Xue, and Jing Cang.
    • Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
    • Neurosci Bull. 2012 Oct 1;28(5):499-508.

    ObjectiveSevoflurane is widely used in pediatric anesthesia and former studies showed that it causes neurodegeneration in the developing brain. The present study was carried out to investigate the effects of sevoflurane on neurogenesis, neurodegeneration and behavior.MethodsWe administered 5-bromodeoxyuridine, an S-phase marker, before, during, and after 4 h of sevoflurane given to rats on postnatal day 7 to assess dentate gyrus progenitor proliferation and Fluoro-Jade staining for degeneration. Spatial reference memory was tested 2 and 6 weeks after anesthesia.ResultsSevoflurane decreased progenitor proliferation and increased cell death until at least 4 days after anesthesia. Spatial reference memory was not affected at 2 weeks but was affected at 6 weeks after sevoflurane administration.ConclusionSevoflurane reduces neurogenesis and increases the death of progenitor cells in developing brain. This might mediate the late-onset neurocognitive outcome after sevoflurane application.

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