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- Nathalie Rives, Jean-Pierre Milazzo, Albanne Travers, Brahim Arkoun, Amandine Bironneau, Louis Sibert, Agnès Liard-Zmuda, Aude Marie-Cardine, Pascale Schneider, Jean-Pierre Vannier, and Bertrand Macé.
- B Acad Nat Med Paris. 2013 Apr 1;197(4-5):877-86; discussion 886.
AbstractThe toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.
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